Authors: Ryden Armstrong Reviewers: Billy Sun Joseph Tropiano Melinda Davis, MD
Propofol Abbreviations GABA – Ga mma-a minobutyric acid
Quick Facts
1° Indication = Induction and maintenance of general anesthesia, sedation
Route of Administration = IV
Metabolism & Excretion = Redistribution, hepatic conjugation/ renal clearance
Legend: Pathophysiology Mechanism
Allosterically increases binding affinity of inhibitory neurotransmitter GABA for GABAA receptor
i
Prolonged opening of chloride channel
1
Hyperpolarization of nerve membrane Inhibitory effect on CNS
I
Induction/maintenance of general anesthesia
Sign/Symptom/Lab Finding
Injection site pain Can pre-treat with intravenous local anesthetic (lidocaine)
4, Cerebral metabolic rate CNS —÷ 4, Cerebral oxygen consumption 4, Intra-cranial pressure
4, Systemic vascular resistance Hypotension ► Cardiovascular –■ —■ (with no change 4, Preload in heart rate) 4, Contractility
Respiratory /
♦ Hypercapnia 4, Hypoxic and –■ hypercapnic Hypoxia respiratory drive ♦ Apnea
4, Upper airway reflexes
Complications I Published MARCH 3, 2018 on www.thecalgaryguide.com
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