po
Authors: Sunny Fong Reviewers: Joseph Tropiano Billy Sun Melinda Davis (MD)
Anticholinergics E.g. Atropine, Glycopyrrolate, Scopolamine
Abbreviations
ACh — Acetylcholine SA — Sino-atrial
Quick Facts
Primary indication in the OR = Combined with acetylcholinesterase inhibitors to prevent over-activation of the parasympathetic nervous system
Route of Administration = IV
Muscarinic (parasympathetic) effects
Competitive antagonism at muscarinic receptors in various organ systems
4, Binding sites for ACh at muscarinic receptors
Blockage of muscarinic ► receptors in SA node (esp. atropine)
► Smooth muscle relaxation in the bronchial airways
4, Respiratory tract mucosal ► secretions (esp. glycopyrrolate, scopola mine)
► Pupillary dilation
Tachycardia
Bronchorelaxation
Respiratory tract clearing
Mydriasis
► 4, Secretion of salivary glands —■ Dry mouth
► 4, Intestinal motility and peristalsis
► 4, Ureter and bladder tone
Constipation
Urinary retention
Legend: Pathophysiology Mechanism Sign/Symptom/Lab Finding Complications I Published March 3, 2018 on www.thecalgaryguide.com
0 0 4SI 0 I’ it En