SEARCH RESULTS FOR: Benzodiazepine-Mechanism-of-Action

benzodiazepine-wirkmechanismus

Benzodiazepine: Wirkmechanismus

Benzodiazepine Mechanism of Action

Benzodiazepine: Mechanism of action Anesthetic composed of a fused benzene and diazepine ring that is administered orally or intravenously to produce a sedative or hypnotic effect Ex. Lorazepam, Midazolam, Diazepam Binds to Gamma- aminobutyric acid (GABAA) receptor in vascular smooth muscle and the central nervous system (CNS) APs inhibited in vascular smooth muscle Vascular smooth muscle relaxes Vasodilation ↓ Blood pressure Authors: Victoria Silva Travis Novak Reviewers: Billy Sun Mao Ding Melinda Davis* *MD at time of publication ↑ Frequency of chloride channel opening Hyperpolarization of nerve membrane Action potential (AP) inhibited APs inhibited in the medulla oblongata (the respiratory center) ↓ Respiratory drive: the body fails to ↑ depth and rate of respirations when arterial CO2 ↑ General CNS inhibition Anti-convulsion (Seizures are caused by a burst of uncontrollable, electrical activity in the brain) APs inhibited in the thalamus and hypothalamus (play a role in memory) APs inhibited in the limbic system (the behavioral and emotional response centers in the brain) Hypotension ↓ Cerebral blood flow ↓CO2 diffusion from arterial blood to alveoli ↓O2 diffusion from alveoli to arterial blood Pharyngeal muscle relaxation ↑ Arterial CO2 ↓ Arterial O2 Airway obstruction Amnesia ↑ PaCO2 ↓ PaO2 ↓ Anxiety Anxiolysis Hypercapnia Hypoxemia In high doses: Depression of arousal and loss of consciousness Induction of general anesthesia (No analgesic effect) ↓ Intracranial pressure Benzodiazepine reversal: Temporary cessation of breathing Apnea Flumazenil competitively binds to GABAA Flumazenil reverses the binding of benzodiazepine to GABAA ↓ Frequency of chloride channel opening Depolarization of nerve membrane Benzodiazepine reversal Legend: Pathophysiology Mechanism Sign/Symptom/Lab Finding Complications Published Aug 09, 2018, updated April 25, 2023 on www.thecalgaryguide.com

Benzodiazepine mechanism of action

Benzodiazepines: Mechanism of action Sedative-hypnotic, anxiolytic & anti-convulsive agents composed of a fused benzene and diazepine ring that is administered orally or intravenously to produce desired effect (ie., lorazepam, midazolam, diazepam) Authors: Tracey Rice Usama Malik Amy Fowler Victoria Silva Reviewers: Sara Cho Keira Britto Luiza Radu Brienne McLane* Aaron Mackie* * MD at time of publication Benzodiazepine binds to gamma-aminobutyric acid (GABAA) receptors in vascular smooth muscle & the central nervous system (CNS) ↑ Opening of chloride channels Influx of chloride ions into the neuron Hyperpolarization of nerve membrane causing it to be more negative The cell membrane falls below the normal resting potential Medulla oblongata inhibition ↓ Respiratory drive; ↓ depth & rate of respirations Temporary cessation of breathing leads to reduced oxygen supply to the brain ↓ Level of consciousness Pharyngeal muscle relaxation leading to obstruction Hypoventilation and/or apnea General CNS inhibition ↓ Neuronal activity ↓ Electrical brain activity ↓ Seizure activity & hypnotic effect Thalamic & hypothalamic inhibition Disruption of short & long- term memory consolidation Limbic system inhibition ↓ Fear emotions (panic & phobia) Anxiolytic effect (↓ Anxiety) Smooth muscle inhibition Smooth muscles become relaxed &/or less spastic Vasodilation ↓ Preload Hypotension ↓ Cerebral blood flow Pre-syncope or syncope Anterograde amnesia ↓ Visuospatial ability, speed of processing & verbal learning Confusion ↓ Deep stage of non-REM sleep & delayed REM sleep Rapid sleep Legend: Pathophysiology Mechanism Sign/Symptom/Lab Finding Complications Published July 21, 2024 on www.thecalgaryguide.com

Benzodiazepine

Benzodiazépine: Mécanisme d'action