SEARCH RESULTS FOR: systemic-lupus-erythematosus-gastrointestinal-manifestations

systemic-lupus-erythematosus-gastrointestinal-manifestations

Systemic Lupus Erythematosus: Gastrointestinal Manifestations Abbreviations: • APLA Phospholipid — Anti-Antibodies 1— Production of auto-antibodies APLA in circulation promotes blood coagulation —01• Thrombosis of vessels in the pancreas Micro-thrombi of vessels in the liver Liver infarcts Thrombosis of vessels in the small intestine Acute Pancreatitis Death of liver cells release contents into blood stream Thrombus in the hepatic vein • Vascular Damage Mesenteric Vasculitis/Ischemia Budd Chiari Syndrome Damage to Auerbach's Plexus 11` Liver Enzymes 1` in capillary permeability Abnormal release of inflammatory cytokines 1 Inflammation in esophageal muscles Protein-Losing Enteropathy Ascites Note: The gastrointestinal manifestations of systemic lupus erythematosus are due to multifactorial and complex causes, some of which are unknown. Legend: Pathophysiology Mechanism Impaired motor innervation Authors: Joseph Tropiano Reviewers: Zaini Sarwar Harjot Atwal Liam Martin* * MD at time of publication Abnormal production of immune complexes Immune complex deposition in blood vessels Immune complex deposition in smooth muscle Inflammatory reaction in the GI tract Immune complex mediated vasculitis Chronic ischemia of bowel smooth muscle Muscular damage Myopathy or neurogenic pathology of the GI muscles GI muscle damage not severe enough to inhibit peristalsis completely Esophageal Motility Disorders Dysphagia Sign/Symptom/Lab Finding Complications Hypomotility Dysmotility