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pertussis-pathogenesis-clinical-findings-and-complications

Pertussis: Pathogenesis, clinical findings and complications Authors: Morgan Sosniuk Yan Yu* Reviewers: Jessica Tjong Crystal Liu Timothy Fu Luis Murguia-Favela* * MD at time of publication Bordetella pertussis bacterium enters the airway via droplets B. pertussis binds to ciliated epithelial cells and multiplies, colonizing the nasopharynx B. pertussis produces multiple toxins (e.g. “pertussis toxin”, “tracheal toxin”) which damage mucosal cells Pertussis toxin produces cyclic AMP (cAMP) and disrupts normal intracellular signalling, impairing the immune response initially Pertussis (“Whooping Cough”) Respiratory syndrome consisting of severe fits of paroxysmal coughing and stridor Nasopharyngeal swab produces positive culture and/or positive PCR result (either is diagnostic) Initial immune dampening allows the bacteria to take hold and begin replicating. During this “incubation period”, the bacteria has not yet replicated to the point of causing symptoms. 1. Catarrhal Stage (5-10 days) After a few days, continued damage to nasopharynx epithelial cells stimulates the immune system to ↑ its response once again 2. Paroxysmal Stage (1-2 weeks) Tracheal cytotoxin released by B. pertussis impairs normal cilia function and ciliary beating in the trachea 3. Convalescent stage (2 weeks - months) Immune defenses successfully eliminate the majority of B. pertussis from the respiratory tract ↑ mucus production from goblet cells of the respiratory epithelium Mucus blocks airway, prevents air entry Collapsed lung Rarely, areas of chest or abdominal wall are weakened, allowing contents to bulge out Hernia ↑ proinflammatory cytokine production Mild fever Cold-like symptoms Mild dry cough, runny nose, sneezing, nasal congestion ↓ fluid clearance from the respiratory tract Fluid in the trachea narrows tracheal diameter “Whooping” cough Severe, rapid and sequential coughing fits, followed by characteristic “whooping” sound on inspiration due to a stridor from a narrower trachea Fluid build up in the lungs Environment more susceptible to co-infection Other bacteria colonize the lungs Pneumonia Paroxysmal coughing fits ↓ in frequency and number Cough may sound louder (mechanism unknown) but overall symptoms ↓ Some B. pertussis still remain Residual cough flares This stage may be prolonged in unvaccinated individuals who eliminate the bacterium more slowly Intense cough can break ribsàsharp rib ends puncture lungàair leaks out ↑ pressure on bladder If weak urethral sphincters: Urinary incontinence Cough ↑ intra- abdominal pressure If dripping mucus triggers gag reflex while a cough is contracting abdominal muscles: Vomiting Coughing fits disrupt regular inspiration and ↓ oxygenation Hypoxia If hypoxia is profound enough to affect brain Seizures Abdominal muscles tire from coughing, and coughing fits make it difficult to sleep Extreme fatigue Rarely, violent coughing causes trauma to head Intracranial hemorrhage Vertebral or carotid dissection Cerebral ischemia Coma or death Notes: • B. pertussis is a Gram- negative strict aerobe • An effective vaccine exists to prevent infection by B. pertussis • Pertussis most commonly infects children <18 months prior to completion of scheduled vaccination series, or adolescents with ↓ immunity Legend: Pathophysiology Mechanism Sign/Symptom/Lab Finding Complications Published October 4, 2020 on www.thecalgaryguide.com Include a sentence! When sending in the final draft of a slide, please include in the email a sentence that describes the slide that you've produced in detail. This will help us boost the relevance of the slide with search engines. E.g., Disease X presents with symptom Y due to pathophysiology Z Pertussis presents with fits of severe paroxysmal coughing due to impaired mucociliary clearance.