SEARCH RESULTS FOR: Vitamin-K-Deficiency

Vitamin K Deficiency

Vitamin K Deficiency: Pathogenesis and Clinical Findings Author: Sean Spence Reviewers: Michael Blomfield, Tony Gu, Tristan Jones, Yan Yu Man-Chiu Poon* Lynn Saviole* * MD at initial time of publication Dietary Deficiency Small bowel bacterial overgrowth Antibiotic use Disruption of normal flora ↓ Gut flora synthesis Vitamin K Deficiency ↓ vitamin K dependent gamma carboxylation of clotting factors II, VII, IX, X Gastrointestinal mucosal diseases (e.g., Celiac disease) Pancreatic insufficiency Cholestasis Malabsorption Exposure to vitamin K antagonists (e.g., warfarin) Inhibition of vitamin K epoxide reductase ↑ bleeding tendency Gastrointestinal tract bleeds Intracranial bleeds Hemarthoses (bleeding into joints) Easy bruising Petechiae, purpura Heavy menstrual bleeds Prolonged PT/INR Note: PT/INR is more sensitive and validated for warfarin monitoring ↓ Activity of intrinsic clotting pathway Prolonged PTT ↓ Activity of extrinsic clotting pathway Legend: Pathophysiology Mechanism Sign/Symptom/Lab Finding Complications Re-Published July 27, 2019 on www.thecalgaryguide.com