SEARCH RESULTS FOR: Uterine-Fibroids

Uterine-Fibroids

Uterine Fibroids (Leiomyomas): Pathogenesis and clinical findings Early Menarche (onset of period) ↑ estrogen exposure in Obesity ↑ adipose tissue ↑ conversion of androgens into estrogen Ethnicity (African) ↑ amount of aromatase enzymes Family History Complex chromosomal rearrangements Myometrial Injury Hypoxia of myometrial cells Low Parity Lack of protective pregnancy-induced remodeling to myometrium Note: Approximately three-quarters of women have fibroids. Of these, only about one-quarter become symptomatic. Fibroids generally decrease in size after menopause and symptoms improve. Intracavitary Fibroid projects into uterine cavity ↑ Endometrial Surface Area ↑ endometrium to proliferate and lose during menstruation Age 40-50 lifetime Estrogen stimulates proliferation of uterine smooth muscle cells Benign proliferation of monoclonal myometrial (uterine wall/muscle) cells into discrete masses Uterine Fibroids (Leiomyomas) Benign tumours originating in and consisting of uterine muscle tissue Fibroids can be located in different areas of the uterus, including the following locations Authors: Emilee Anderson Reviewers: Danielle Chang Crystal Liu Yan Yu* Aysah Amath* * MD at time of publication Subserosal Fibroid grows adjacent to perimetrium into uterine muscle Enlarged uterus or pelvic mass on bimanual exam Irregularities in uterine cavity Transformation of normal myocytes into abnormal myocytes Submucosal Fibroid grows adjacent to endometrium into uterine muscle Intramural Fibroid is within the thickness of the myometrium Pedunculated Fibroid extends into pelvic cavity or uterine cavity on a stalk Spherical mass on ultrasound Fibroid ↑ intra-abdominal pressure and puts pressure on adjacent organs Enlarged Uterine/Pelvic Mass Repeat shedding over time Iron Deficiency Anemia Pelvic Pain Compression of stomach Fibroid takes up space Enlarged Abdomen Fibroid puts pressure on the cervix Dyspareunia Fibroid compress the bladder Urinary incontinence Fibroid compress the bladder outlet Difficulty with voiding Fibroid compress rectum Constipation Embryo cannot implant Infertility and/or recurrent pregnancy loss Menorrhagia Dysmenorrhea Sensation of abdominal fullness Early Satiety Legend: Pathophysiology Mechanism Sign/Symptom/Lab Finding Complications Published November 5, 2020 on www.thecalgaryguide.com

Uterusmyom (Leiomyom): Pathogenese und klinische Befunde

Uterusmyom (Leiomyom): Pathogenese und klinische Befunde