SEARCH RESULTS FOR: Fibromylagia

Fibromylagia

Fibromyalgia: Pathogenesis and clinical findings Authors: Modhawi Alqanaie Reviewers: Mao Ding Kevin Zhan Luiza Radu Gary Morris* *MD at time of publication ↑ Substance P (a potent pain mediator neuropeptide) in cerebrospinal fluid ↑ Glutamate (pro- nociceptive excitatory neurotransmitter) ↑ Nerve growth factor ↑ Propagation of pain signals ↓ Norepinephrine ↓ Serotonin Hyperactive nociceptors (nerve cell endings for pain sensation) ↓ Polarization of afferent sensory neurons ↓ Suppression of pain transmission at the nociceptive spinal cord Underactive inhibitory pathway Central sensitization (amplifying neural signal to perceive pain from a non-painful stimuli) Fibromyalgia Syndrome Hypersensitivity to pressure (tender points) Muscle spasm (involuntary contraction of a muscle) Allodynia (pain to a non-painful stimulus) Nocturnal awakening Sleep disturbance Chronic stress and tension Depression Prolonged cortisol elevation Diffuse hyperalgesia (increased pain to pressure) Persistent activation of peripheral pain receptors Ongoing tissue injury Chronic pain Possible metabolic changes Mitochondrial dysfunction Oxidative stress (imbalance between free radicals and antioxidants) Muscle fiber dysfunction Reduced muscle oxidative capacity Muscle fatigue Low energy Systemic production of eotaxin chemokines and IL-10 cytokines Disturbances in neural networks ↓ Attentional capacity Mood fluctuations ↑ Irritability Social isolation Dysesthesia (abnormal feelings of itching, stinging, tingling, or general tightening) Muscle and joint stiffness Changes in frontal cortex Deficits in cognitive functions Memory issues Hippocampal atrophy Brain fog Legend: Pathophysiology Mechanism Sign/Symptom/Lab Finding Complications Published Nov 22, 2024 on www.thecalgaryguide.com