SEARCH RESULTS FOR: Bullous-Pemphigoid

Bullous Pemphigoid

Bullous Pemphigoid: Pathogenesis and clinical findings Certain medications (e.g. antibiotics, diuretics, biologics) Author: Danny Guo Mina Youakim Reviewers: Yan Yu Shahab Marzoughi Jason Baserman Laurie Parsons* Régine Mydlarski* * MD at time of publication Preceding disease triggers Infections (e.g. Human Herpes Physical/Environmental triggers (e.g. (e.g. Psoriasis, Lichen Planus) virus, Epstein-Barr virus) Phototherapy, radiotherapy, burns) Development of autoantibodies against the basement membrane antigens (i.e. BPAG1 and BPAG2) (can occur anywhere on the body) Autoimmune destruction of the basement membrane Antibodies activate the complement system and recruit inflammatory cells Further weakened adhesion between epidermis and dermis Accumulation of extracellular serous fluids in a pseudo- pocket between the epidermis and the dermis Unknown etiologies Circulating Immunoglobulin G & E antibodies trigger either a prodrome or concurrent itch response (exact mechanism unknown) Pruritis (itch) Epidermal layer Serous fluid pocket Urticaria (hives) Widespread Bullae (serum-filled lesions) Epidermal layer Dermal-Epidermal Junction Dermal layer Antibody against keratinocytes and Disrupted Dermal-Epidermal Junction Y hemidesmosomes Normal Skin Bullous Pemphigoid Legend: Pathophysiology Mechanism Sign/Symptom/Lab Finding Complications Published Nov 1, 2012; updated Apr 20, 2024 on www.thecalgaryguide.com Y Y Y