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SEARCH RESULTS FOR: Acute-Wound-Healing

Penyembuhan Luka Akut: Patogenesis dan Temuan Klinis

Penyembuhan Luka Akut: Patogenesis dan Temuan Klinis Tusuk Lecet Remuk Cedera Kulit Akut Iskemia Tekanan berlebih suplai darah dan oksigenasi • Kerusakan Kulit Utuh Gangguan struktur dan fungsi jaringan dermis, epidermis dan subdermal Note: Kernampuan penyembuhan luka bergantung pada: • Asal Trauma • Adanya Infeksi • Adanya Benda Asing • Iskemia Jaringan • Vaskularitas • Tingkat edema atau peningkatan tekanan jaringan Legenda: Infla• masi (pada lapisan kulit terganggu) • 0 — 7 hari Proliferasi (kolagen, matriks ekstrasel & pembuluh darah) 4 - 14 hari Remodeling ► (.j, pemb. darah & kolagen tersusun) Lapisan Epidermis Batas Dermis-Epidermis Lapisan Dermis Vasokonstriksi transien Pembentukan sumbat platelet Jejas endotel dan subendotel mengaktivasijalur koagulasi Sel mast melepaskan histamin merespon iritan Penulis: Amanda Eslinger Penyunting: Heena Singh Yan Yu Laurie Parsons* Penedemah: M Harmen Reza S* * MD (dokter) pada saat publikasi Inflamasi I Proliferasi I Remodeling Perdarahan berkurang atau berhenti karena sumbat hemostatik (hemostasis) Permeabilitas pemb. kecil terhadap neutrofil & makrofag Aktivasi komplemen memicu sel endotel sekitar untuk melepaskan prostaglandins TGF-8*, dibentukselama fase inflamasi, menarikfibroblas ke daerah luka Klot Menyatukan Ujung luka Perdarahan Leukosit proliferasi dan menyapu kotoran dan bakteri 1 Suplai vaskuler dan vasodilatasi di daerah luka Makrofag melepaskan transforming growth factor beta (TGF-8) * -110. 1' Tekanan hidrostatik mendorong cairan dari pembuluh jaringan sekitar Fibroblas& makrofag menstimulasi pertumbuhanjaringan dan angiogenesis yang menggantikan sumbat hemostatik. Akhirnya, reepiteliasisasi terjadi 8 — 365+ hari Patofisiologi Mekanisme Kolagen tipe 1 yang mengalami tautan silang secara luas menggantikan kolagen yang berserakan yang tersusun pada fase proliferasi Tanda/Gejala/Hasil Lab Komplikasi Luka Sembuh kadar —* protein dalam kolagen Eritema Edema Keropeng Penyembuhan Luka Parut (Scar)

Acute Wound Healing

↓ Blood supply and oxygenation to local skin tissue Ischemia Degradation of intact skin Abrasion (damage by scrape/rub) Puncture (small piercing caused by sharp object) Acute injury to the skin Crush (damage by compression) Acute Wound Healing: Pathogenesis and clinical findings Author: Amanda Eslinger Mina Youakim Reviewers: Heena Singh Shahab Marzoughi Yan Yu Laurie Parsons* * MD at time of publication 8 – 365+ days post-injury Remodeling (↓ blood vessels & organized collagen) Extensively cross-linked type 1 collagen replaces the disorganized collagen laid down in the proliferative phase ↑ Protein content in collagen Scarring (fibrotic tissue replaces previously healthy tissue) Disruption of structure and function of dermis, epidermis and subdermal tissues Subendothelial and endothelial damage activates the coagulation pathway Formation of a platelet plug Bleeding is slowed or stopped by hemostatic plug (hemostasis) Clot unifies wound edges 0 – 7 days post-injury Inflammation (In disrupted skin layers) 4 - 14 days post-injury Proliferation of collagen, extracellular matrix & blood vessels TGF-β attracts fibroblasts to the site of the wound Fibroblast & macrophage stimulate tissue growth & angiogenesis which replaces hemostatic plug Scabbing (protective crust overlying damaged tissue) Re-epithelialization beneath the scab sloughs it off Healing (newly replaced tissue replaces damaged one) In response to irritant, mast cells release histamine Complement activation causing nearby endothelial cells to release prostaglandins Vasodilation occurs around the wound area Localized ↑ vascular supply (reception of blood and fluid from vessels) ↑ Hydrostatic pressure forces fluid from vessels into surrounding tissue Edema (swelling from fluid buildup) Erythema (redness) Legend: Pathophysiology Mechanism Sign/Symptom/Lab Finding Complications First Published Sept 19, 2013; updated Jan 30, 2024 on www.thecalgaryguide.com