SEARCH RESULTS FOR: Acne-Vulgaris-Complications

Acne Vulgaris Complications

Acne vulgaris: Complications Acne vulgaris Cutaneous inflammation caused by acne lesions True Scars Authors: Stephen Williams Reviewers: Mehul Gupta, Lauren Lee, Yan Yu*, Laurie Parsons* * MD at time of publication Elevated Acne Scars ↑ collagen exceeds collagen degradation Prostaglandins (PGE2), leukotrienes (LTC4, LTD4), and thromboxane A2 are released in response to inflammation Atrophic Acne Scars Collagen degradation and disordered deposition during healing Formation of round- rectangular depressions with defined edges Box Car Scar True scars with textural change, very slow autoresolution over time The pigmentary changes and true scar formation resulting from acne may be more psychologically distressing than the original acne lesions Healing processes favoring deposition of Type 1 & Type 3 collagen Proliferation beyond the borders of original acne lesion Keloid Formation Healing processes favoring deposition of Type 4 collagen Growth remains within the margins of acne lesion Hypertrophic Scar Formation Dermal inflammation: Due to disruption of basal cell layer, melanin released and trapped by macrophages in the dermis. Epidermal inflammation: ↑ melanin production and transfer of melanin to keratinocytes Microvascular dilatation and ↑presence of erythrocytes Erythematous macules appear where acne was present Post- inflammatory Erythema (PIE). More common in Fitzpatrick Skin Types I-III Formation of V- shaped tracts with sharp margins Ice Pick Scar Formation of a shallow edged depression layer anchored to dermal layer and subcutis Rolling Scar Pigmented macules or patches appear where acne was present Post-inflammatory Hyperpigmentation (PIH). More common in Fitzpatrick Skin Types III-VI No textural change, slow autoresolution over time True scars with textural change, do not resolve over time Psychosocial Concerns (Depression, Anxiety, Social Isolation) Legend: Pathophysiology Mechanism Sign/Symptom/Lab Finding Complications Published October 19, 2021 on www.thecalgaryguide.com