Bronchopulmonary Dysplasia (BPD)- Pathogenesis and clinical findings Adderley Mitchell antenatal post-natal prematurity intrauterine growth restriction genetic predisposition maternal smoking chorioamnionitis pregnancy induced hypertensive disorders post natal mechanical ventilation sepsis O2 toxicity patent ductus arteriosus insult to lungs pro inflammatory cytokines disruption pulmonary vascular alveolar development reduced pulmonary vascular resistance vascular growth and altered vasoreactivity
dysmorphic capillary beds remodelling of pulmonary arteries artery hypertension suboptimal repair abnormal remodelling interstitial fibrosis diffuse haziness interstitial thickening cxr impaired pulmonary gas exchange hypoxia signs of respiratory distress retractions wheezes crackles DLCO airway resistance obstructive lung disease FEV1 separation and alveolar hypoplasia functional alveoli surface area gas exchange